Migraine Headaches: Unraveling the Mystery, Causes, Triggers, Treatments, and Management

headaches migraine


Migraine headaches, characterized by throbbing pain, sensitivity to light and sound, and often accompanied by nausea and vomiting, affect millions of people worldwide. Despite their prevalence, migraines remain a complex and enigmatic neurological condition. In this comprehensive guide, we’ll delve into the world of migraines, exploring their causes, triggers, symptoms, diagnosis, treatment options, and effective management strategies.

Section 1: Understanding Migraines

Defining Migraine Headaches

A migraine is not merely a severe headache but a neurological disorder with specific symptoms and characteristics. Understanding the unique features of migraines is the first step to managing this condition effectively.

Migraine vs. Tension Headache

Distinguishing between migraines and tension headaches is crucial. Migraines typically involve moderate to severe pain, often on one side of the head, and are accompanied by other symptoms like nausea and sensitivity to light and sound. Tension headaches, on the other hand, are typically described as a constant, dull ache with fewer associated symptoms.

Migraines are often described as “pounding” or “throbbing” in nature, and they can last from a few hours to several days. In contrast, tension headaches are often characterized by a constant, band-like pressure around the head.

Migraine Variants

Migraines come in various forms, each with its own set of features. Exploring these variants can help individuals recognize and manage their specific migraine subtype.

Common Migraine

Common migraines are characterized by moderate to severe pain and are often preceded by an “aura” – visual disturbances that serve as a warning sign of an impending headache. These auras can include seeing flashing lights, zigzag lines, blind spots, or experiencing tingling sensations in the face or hands. However, not all migraines involve an aura.

Classic Migraine

Classic migraines also involve an aura but with more pronounced visual disturbances, such as zigzag lines or blind spots. These auras typically last for 20 minutes to an hour and are followed by the headache phase.

Menstrual Migraine

Menstrual migraines are linked to hormonal fluctuations and tend to occur in the days leading up to or during menstruation. The hormonal changes that trigger these migraines can make them particularly challenging to manage.

Vestibular Migraine

Vestibular migraines cause dizziness and balance problems, often without the classic headache pain. These migraines can be especially disorienting and are often underdiagnosed.

The Role of Triggers

Migraine triggers can vary widely among individuals. Identifying and managing these triggers is essential for preventing migraine attacks. Common triggers include:

  • Dietary Factors: Certain foods and drinks, such as aged cheeses, processed meats, caffeine, and alcohol, can trigger migraines in susceptible individuals.
  • Hormonal Changes: Fluctuations in estrogen levels, often experienced by women during their menstrual cycles, pregnancy, or menopause, can trigger migraines.
  • Environmental Factors: Sensory stimuli, such as bright lights, loud sounds, or strong odours, can trigger migraines. Weather changes and barometric pressure shifts may also be associated with migraine onset.
  • Stress: High stress levels can trigger migraines in many individuals. Stress-reduction techniques are often recommended as part of migraine management.

Section 2: The Anatomy of a Migraine Attack

Understanding the physiological changes that occur during a migraine attack sheds light on the complexity of this condition.

Migraine Phases

Migraines typically progress through four distinct phases, each with its own set of symptoms:

1. Prodrome Phase

The prodrome phase precedes the headache and can include subtle changes in mood, appetite, or energy levels. These early warning signs can serve as indicators that a migraine attack is imminent.

2. Aura Phase

Not all migraine sufferers experience auras, but for those who do, this phase can involve visual disturbances, sensory changes, and difficulty with speech or language. Auras often act as a forewarning of an impending migraine, allowing individuals to take preventive measures.

3. Headache Phase

The headache phase is the most recognizable, marked by intense throbbing pain that can last for hours to days. This phase is often accompanied by other symptoms, such as nausea, vomiting, and extreme sensitivity to light and sound.

4. Postdrome Phase

After the headache subsides, individuals may feel fatigued, disoriented, and emotionally drained. This postdrome phase can last for hours or even days after the headache, and individuals often describe feeling “washed out.”

The phases of a migraine attack are not always experienced in the same way, and not all individuals with migraines go through every phase. Understanding the specific phases one experiences can help in managing and coping with migraine attacks.

Section 3: Causes and Risk Factors

Migraines have a complex interplay of genetic, environmental, and neurological factors that contribute to their onset and frequency.

Genetic Predisposition

A family history of migraines significantly increases the likelihood of experiencing migraines. If one or both parents have a history of migraines, the risk of developing migraines is higher.

Migraines are believed to have a genetic component, and several genes have been associated with an increased risk of migraines. However, the inheritance pattern is complex, and many factors beyond genetics contribute to the development of migraines.

Neurological Factors

Migraines involve abnormal brain activity, including the release of neuropeptides like calcitonin gene-related peptide (CGRP), which play a role in inflammation and pain perception. Researchers have identified that CGRP levels tend to increase during a migraine attack.

Studies have also shown that changes in brain blood flow and electrical activity occur during a migraine, particularly in the aura phase. Understanding these neurological changes is a crucial area of research for migraine treatment and prevention.

Hormonal Triggers

Hormonal fluctuations, particularly in women, can trigger migraines. Understanding the relationship between hormones and migraines is crucial, especially for women experiencing menstrual migraines.

  1. Menstrual Migraines: As mentioned earlier, hormonal fluctuations related to the menstrual cycle can trigger migraines in some women. These migraines often occur in the days leading up to menstruation, during menstruation, or in the days following menstruation. The drop in estrogen levels is believed to be a key trigger.
  2. Pregnancy and Migraines: Pregnancy can have a variable impact on migraines. Some women experience fewer migraines during pregnancy, particularly in the second and third trimesters when estrogen levels are relatively stable. However, migraines can also worsen during pregnancy, especially during the first trimester when hormone levels fluctuate.
  3. Menopause and Migraines: Menopause is a significant hormonal transition for women. Some women experience relief from migraines after menopause, as hormone levels stabilize. However, for others, migraines may persist or even worsen during this time.

Environmental Factors

Sensory stimuli, such as bright lights, loud sounds, or strong odours, can trigger migraines. Weather changes and barometric pressure shifts may also be associated with migraine onset. Common environmental triggers include:

  1. Light Sensitivity (Photophobia): Many individuals with migraines are sensitive to light during an attack. Exposure to bright or flickering lights can worsen symptoms or even trigger an attack. Wearing sunglasses and seeking out dark, quiet spaces can help alleviate discomfort.
  2. Sound Sensitivity (Phonophobia): Loud noises, especially sudden or sharp sounds, can trigger migraines or worsen headache pain. Wearing noise-cancelling headphones or using earplugs can be helpful.
  3. Odor Sensitivity: Some individuals are highly sensitive to strong odours, such as perfumes, cigarette smoke, or certain chemicals. Avoiding such triggers can reduce the likelihood of migraine attacks.
  4. Weather Changes: Weather-related triggers are less common but still significant for some individuals. Changes in barometric pressure, humidity, and temperature can contribute to the onset of migraines. While weather patterns are beyond one’s control, awareness of this trigger can help individuals prepare and manage their condition accordingly.

Section 4: Diagnosis

Reaching a definitive diagnosis of migraine involves careful evaluation of symptoms, medical history, and, in some cases, imaging studies.

Diagnostic Criteria

The International Classification of Headache Disorders (ICHD) provides diagnostic criteria for migraines, which include the duration, frequency, and characteristics of headache attacks. To receive a formal diagnosis of migraine, a patient’s symptoms must meet specific criteria outlined in the ICHD guidelines.

  1. Recurrence: Migraines are recurrent, with the number of headache days varying from patient to patient.
  2. Duration: A migraine attack typically lasts from 4 to 72 hours when untreated or unsuccessfully treated.
  3. Characteristics: The headache is typically described as pulsating, moderate to severe in intensity, and often located on one side of the head. It is accompanied by other symptoms such as nausea, vomiting, and sensitivity to light and sound.
  4. Positive Response to Medications: Migraines typically respond well to migraine-specific medications, like triptans or ergot derivatives.

Medical Evaluation

A thorough medical evaluation helps rule out other potential causes of headaches, ensuring an accurate diagnosis of migraines. When individuals seek medical help for their headaches, healthcare providers perform a comprehensive evaluation that may include:

  1. Medical History: A detailed medical history is taken to understand the patient’s headache pattern, family history of headaches, and any potential triggers.
  2. Physical Examination: A physical examination is conducted to check for neurological abnormalities and to rule out other potential causes of headache.
  3. Neurological Examination: This examination focuses on the nervous system to detect any abnormalities that may be related to the headache.
  4. Diagnostic Tests: In some cases, diagnostic tests such as MRI or CT scans may be recommended to rule out other underlying conditions. These tests help ensure that there are no structural issues in the brain causing the headaches.
  5. Blood Tests: Blood tests can help identify underlying medical conditions that might be contributing to the headaches. For example, elevated levels of certain substances in the blood may indicate an inflammatory process.

Imaging Studies

In certain cases, imaging studies like MRI or CT scans may be recommended to rule out other underlying conditions. While migraines are typically diagnosed based on clinical criteria and patient history, imaging studies are useful in cases where there are atypical features, new neurological symptoms, or concerns about other potential conditions.

MRI (Magnetic Resonance Imaging) provides detailed images of the brain’s structure, and it can help detect abnormalities such as tumours, vascular malformations, or other structural issues.

CT (Computed Tomography) scans use X-rays to create cross-sectional images of the brain. These scans are particularly useful in detecting acute issues like bleeding, but they are not as sensitive as MRI for identifying certain brain abnormalities.

Section 5: Treatment Options

Various treatment strategies are available to manage migraine symptoms, reduce the frequency of attacks, and improve overall quality of life.

Acute Treatment

Acute treatments are aimed at relieving the pain and associated symptoms during a migraine attack. Medications like triptans, NSAIDs, and anti-nausea drugs can be effective. The choice of acute treatment often depends on the individual’s specific symptoms, the severity of the attack, and any contraindications.

  1. Triptans: Triptans are a class of medications that specifically target migraine attacks. They work by constricting blood vessels and blocking pain pathways in the brain. These medications can effectively relieve pain, nausea, and other migraine symptoms when taken at the onset of an attack.
  2. NSAIDs (Non-Steroidal Anti-Inflammatory Drugs): NSAIDs like ibuprofen or naproxen can be used for mild to moderate migraines. They work by reducing inflammation and pain. However, they may be less effective for severe migraines.
  3. Anti-Nausea Medications: Nausea is a common symptom of migraines. Anti-nausea medications can be prescribed or purchased over the counter to alleviate this symptom. They can be taken alone or in combination with other migraine medications.
  4. Opioid Medications: Opioids are strong pain relievers and are sometimes used when other treatments are ineffective. However, their use is generally limited due to the risk of dependence and other side effects.

Preventive Treatment

For individuals with frequent or severe migraines, preventive treatments may be recommended. These include medications like beta-blockers, anticonvulsants, or CGRP inhibitors. Preventive treatments are considered when the following criteria are met:

  • The individual experiences four or more headache days per month.
  • The headaches significantly interfere with daily activities and quality of life.
  • Acute treatments are ineffective, cause intolerable side effects, or are contraindicated.
  • The patient prefers to reduce the use of acute migraine medications.

Preventive medications are taken regularly, usually on a daily basis, to reduce the frequency and severity of migraine attacks. These medications do not provide immediate relief during an active attack but are intended to reduce the overall number of attacks over time.

  1. Beta-Blockers: Beta-blockers, which are commonly used to treat high blood pressure and heart conditions, can be effective in preventing migraines. Medications like propranolol and metoprolol are often prescribed for this purpose.
  2. Anticonvulsants: Certain anticonvulsant medications, such as topiramate, valproic acid, and gabapentin, have been found to reduce the frequency of migraines. These medications are thought to stabilize electrical activity in the brain.
  3. CGRP Inhibitors: CGRP inhibitors are a relatively new class of preventive medications designed specifically for migraine prevention. They work by targeting the neuropeptide CGRP, which plays a role in migraine pathophysiology. CGRP inhibitors include medications like erenumab, fremanezumab, and galcanezumab.
  4. Antidepressants: Some antidepressant medications, such as amitriptyline and venlafaxine, can be used for migraine prevention. These medications may work by modulating pain pathways in the brain and reducing the frequency of attacks.
  5. Botox (OnabotulinumtoxinA): Botox injections have been approved by the FDA for the prevention of chronic migraines (defined as 15 or more headache days per month). Botox is injected into specific areas of the head and neck and is believed to block pain signals.

Non-Medical Approaches

Non-pharmacological approaches to migraine management include lifestyle modifications, stress reduction, dietary changes, and biofeedback.

  1. Lifestyle Modifications: Lifestyle factors can significantly impact the frequency and severity of migraines. Identifying and modifying these factors can be an essential part of migraine management. Some common lifestyle changes include maintaining a regular sleep schedule, staying hydrated, and avoiding excessive caffeine consumption.
  2. Stress Reduction: Stress is a known trigger for migraines in many individuals. Stress-reduction techniques such as meditation, mindfulness, yoga, and deep breathing exercises can help reduce the likelihood of stress-induced migraines.
  3. Dietary Changes: Identifying and avoiding dietary triggers is crucial for individuals prone to food-related migraines. Common dietary triggers include caffeine, alcohol, processed foods, and certain food additives. Keeping a detailed food diary can help pinpoint specific triggers.
  4. Biofeedback: Biofeedback is a technique that teaches individuals to control physiological processes such as muscle tension and heart rate. It has been used as a complementary therapy for migraine prevention, helping individuals recognize and control physical signs of stress and tension that may contribute to migraine attacks.

Section 6: Lifestyle and Dietary Management

Lifestyle and dietary factors play a significant role in managing migraines. Identifying and addressing these factors can help reduce the frequency and severity of migraine attacks.


Establishing a regular sleep schedule, practising good sleep hygiene, and ensuring adequate sleep duration are essential for migraine management. Poor sleep can trigger migraines in some individuals, and disrupted sleep patterns can make migraines more difficult to manage. Recommendations for promoting healthy sleep include:

  • Consistent Sleep Schedule: Going to bed and waking up at the same time every day helps regulate the body’s internal clock and improves sleep quality. Maintaining a consistent sleep schedule, even on weekends, can reduce the risk of sleep-related migraine triggers.
  • Optimal Sleep Environment: Creating a comfortable sleep environment involves controlling factors such as room temperature, noise, and light exposure. Using blackout curtains, earplugs, and a comfortable mattress can contribute to better sleep quality.
  • Limiting Stimulants: Caffeine, nicotine, and alcohol can disrupt sleep. Limiting their consumption, especially close to bedtime, is advisable. Caffeine, in particular, is a known migraine trigger for some individuals.
  • Physical Activity: Regular exercise has been shown to improve sleep quality. However, it’s essential to time physical activity appropriately, as vigorous exercise too close to bedtime can have the opposite effect. Engaging in physical activity earlier in the day can promote better sleep.

Stress Management

Stress reduction techniques are a key component of migraine management, as stress is a common trigger for migraine attacks. Implementing stress management strategies can help individuals reduce the frequency and severity of migraines. Techniques that have been found to be effective include:

  • Meditation: Meditation involves focusing one’s mind on a particular object, thought, or activity to train attention and awareness. Regular meditation practice can help reduce stress and improve overall well-being.
  • Mindfulness: Mindfulness is the practice of staying fully present in the moment, acknowledging and accepting one’s feelings, thoughts, and bodily sensations without judgment. Mindfulness techniques are often used to manage stress and prevent migraines.
  • Yoga: Yoga combines physical postures, breathing exercises, and meditation to promote physical and mental well-being. It can be an effective way to reduce stress and improve overall health.
  • Biofeedback: Biofeedback involves using electronic monitoring to provide individuals with real-time information about physiological processes such as muscle tension and heart rate. By learning to control these processes, individuals can reduce stress and tension, potentially preventing migraine attacks.


Dietary factors can play a significant role in triggering migraines in some individuals. Identifying and avoiding dietary triggers can be an effective way to reduce the frequency and severity of migraines. Common dietary triggers include:

  • Caffeine: Caffeine is found in coffee, tea, soft drinks, and chocolate. While some individuals find caffeine to be a headache remedy, excessive caffeine consumption can trigger migraines in others. It’s important for individuals to monitor their caffeine intake and determine whether it is a trigger for their migraines.
  • Alcohol: Alcohol, particularly red wine, beer, and certain spirits, is a well-known trigger for migraines. The exact mechanism by which alcohol triggers migraines is not fully understood, but it is believed to involve changes in blood vessels and neurotransmitter imbalances.
  • Tyramine: Tyramine is a naturally occurring compound found in aged cheeses, processed meats, and some fermented foods. For some individuals, tyramine-rich foods can trigger migraines. Avoiding or limiting the consumption of these foods can be beneficial.
  • Food Additives: Certain food additives, such as monosodium glutamate (MSG) and artificial sweeteners, have been associated with migraines in some individuals. Reading food labels and avoiding products containing these additives can help reduce the risk of dietary triggers.
  • Dehydration: Dehydration is a recognized migraine trigger. Staying well-hydrated by drinking an adequate amount of water throughout the day is essential for migraine prevention. Individuals prone to migraines should be particularly vigilant about maintaining proper hydration.


Dehydration is a recognized migraine trigger. Maintaining proper hydration is vital for reducing the risk of migraines. Dehydration can lead to changes in blood volume and electrolyte imbalances, both of which can contribute to the development of migraines.

To stay adequately hydrated and reduce the risk of dehydration-triggered migraines, individuals should:

  • Drink an appropriate amount of water each day. The recommended daily water intake varies by age, sex, and activity level, but a general guideline is to aim for eight 8-ounce glasses of water per day.
  • Be mindful of factors that can increase the risk of dehydration, such as hot weather, physical activity, and alcohol consumption.
  • Listen to the body’s signals for thirst and respond promptly by drinking water.
  • Monitor urine colour as a simple way to gauge hydration. Clear or pale yellow urine is a sign of good hydration, while dark yellow or amber urine may indicate dehydration.
  • Consider including hydrating foods in the diet, such as water-rich fruits and vegetables.

Section 7: Emerging Therapies

Ongoing research is continually expanding the field of migraine management. Several innovative approaches are showing promise for the treatment of migraines.

CGRP Inhibitors

CGRP inhibitors are a novel class of medications designed specifically for migraine prevention. They work by targeting the neuropeptide CGRP, which plays a role in migraine pathophysiology. CGRP is a key player in the development of migraine symptoms, particularly during the headache phase. By blocking the effects of CGRP, these medications can reduce the frequency and severity of migraine attacks.

The FDA has approved several CGRP inhibitors for the prevention of migraines, and more are in development. These medications are administered as injections and are typically taken once a month or less frequently, depending on the specific medication.

CGRP inhibitors have been shown to significantly reduce the number of migraine days experienced by individuals with chronic and episodic migraines. They are considered well-tolerated, with few side effects reported in clinical trials. However, they are relatively new, and long-term safety data is still being collected.

Neuromodulation Devices

Neuromodulation devices, such as transcranial magnetic stimulation (TMS) and non-invasive vagus nerve stimulation (nVNS), are emerging as non-pharmacological options for migraine management. These devices work by influencing neural pathways and brain activity related to migraines.

  1. Transcranial Magnetic Stimulation (TMS): TMS is a non-invasive technique that uses magnetic fields to stimulate specific areas of the brain. It has been approved by the FDA for the treatment of migraines with aura. TMS devices are designed for at-home use and are applied to the back of the head during a migraine attack.
  2. Non-Invasive Vagus Nerve Stimulation (nVNS): nVNS devices deliver electrical impulses to the vagus nerve, which plays a role in regulating pain and inflammation. nVNS is used as an acute treatment for migraines and is typically applied to the neck during an attack.

These neuromodulation devices offer a drug-free option for migraine relief, making them an attractive choice for individuals who prefer non-pharmacological approaches or experience side effects with medication.

Section 8: Coping Strategies and Support

Migraines can have a significant impact on an individual’s quality of life. Coping strategies, emotional support, and education about the condition are invaluable for individuals dealing with migraines.

Coping Strategies

Managing migraines can be challenging, but several coping strategies can help individuals navigate their condition effectively. These strategies include:

  1. Self-Care: Prioritizing self-care is essential for migraine management. This includes getting enough sleep, eating a balanced diet, staying hydrated, and engaging in regular physical activity.
  2. Stress Reduction: Reducing stress through techniques like meditation, yoga, or biofeedback can help prevent migraine attacks. It’s important for individuals to find stress reduction methods that work for them.
  3. Migraine Diary: Keeping a migraine diary to track the frequency, duration, and potential triggers of migraine attacks is a valuable tool for managing the condition. Identifying patterns can help individuals make informed decisions about treatment and prevention.
  4. Treatment Adherence: Adhering to the prescribed treatment plan is crucial. Individuals should take their medications as directed, attend follow-up appointments, and communicate with their healthcare provider about any concerns or side effects.
  5. Healthy Lifestyle: Making healthy lifestyle choices, including maintaining a balanced diet and regular exercise, can improve overall well-being and potentially reduce the frequency of migraines.

Support Systems

Having a support system in place is vital for individuals with migraines. Friends and family can offer emotional support and understanding, and it’s essential for loved ones to be informed about the condition.

Support groups and online communities provide an opportunity to connect with others who are experiencing similar challenges. These platforms offer a space for sharing experiences, coping strategies, and resources. Many national and international organizations dedicated to headache disorders, such as the American Migraine Foundation and The Migraine Trust, offer support and resources for individuals with migraines.

Education and Advocacy

Educating oneself about migraines and becoming an advocate for one’s own health can lead to better outcomes. Knowledge about the condition, treatment options, and available resources empowers individuals to actively participate in their care.

Advocacy efforts can help raise awareness about migraines, reduce stigma, and promote research for improved treatments. Individuals can get involved by participating in migraine-related events, fundraising, and supporting initiatives that advance migraine research and education.

Section 9: When to Seek Medical Attention

While many individuals can effectively manage migraines with lifestyle changes and over-the-counter medications, there are instances when medical attention is crucial.

Red Flags

Certain “red flags” should prompt immediate medical evaluation. These include:

  • Sudden and Severe Headache: A sudden, severe headache that is different from an individual’s usual migraine attacks can be a sign of a medical emergency, such as a hemorrhagic stroke. Seek medical attention immediately.
  • Headache with Neurological Symptoms: Headaches accompanied by severe neurological symptoms, such as confusion, slurred speech, weakness on one side of the body, or loss of consciousness, require immediate medical evaluation.
  • “Thunderclap” Headache: A “thunderclap” headache is an extremely severe headache that comes on suddenly and peaks within seconds to minutes. This type of headache can be a sign of serious medical conditions, including bleeding in the brain or an arterial tear. Seek emergency care.
  • First or Worst Migraine: If an individual experiences their first migraine attack or the most severe headache of their life, medical evaluation is recommended to rule out underlying issues.
  • Migraine With Aura for the First Time After Age 40: The first occurrence of migraine with aura in individuals over the age of 40 should be evaluated by a healthcare provider to rule out other potential causes.

Frequent and Disabling Migraines

Individuals who experience frequent and disabling migraines that significantly interfere with daily life, despite self-care measures and over-the-counter medications, should seek medical attention. A healthcare provider can help develop a tailored treatment plan that may include prescription medications and preventive strategies.

Section 10: Conclusion

Migraine headaches are a complex and often debilitating neurological condition that affects millions of individuals worldwide. Understanding the various aspects of migraines, from their causes and triggers to treatment options and coping strategies, is essential for effective management.

By building a comprehensive understanding of migraines, individuals can better manage their symptoms, reduce their impact on daily life, and work toward a future with fewer migraine attacks and improved overall well-being. Ongoing research and innovative treatments are expanding the possibilities for migraine management, offering hope to those who live with this challenging condition.

Migraines may not yet have a cure, but with the right knowledge and support, individuals can take control of their migraines and lead fulfilling lives.


[Note: This is not an exhaustive list of references, but a selection of key sources.]

  1. Lipton, R. B., et al. (2015). Migraine prevalence, disease burden, and the need for preventive therapy. Neurology, 85(5), 463-472.
  2. Buse, D. C., et al. (2013). Impact of migraine on the family: Perspectives of people with migraine and their spouse/domestic partner in the CaMEO study. Mayo Clinic Proceedings, 88(6), 541-549.
  3. American Migraine Foundation. (2021). The four phases of a migraine attack. https://americanmigrainefoundation.org/resource-library/the-four-phases-of-a-migraine-attack/
  4. Goadsby, P. J. (2012). The pharmacology of headache. Progress in Neurobiology, 97(2), 159-167.
  5. Loder, E., et al. (2012). The 2012 AHS/AAN guidelines for prevention of episodic migraine: A summary and comparison with other recent clinical practice guidelines. Headache, 52(6), 930-945.
  6. Diamond, S., et al. (2000). Patterns of diagnosis and acute and preventive treatment for migraine in the United States: Results from the American Migraine Prevalence and Prevention Study. Headache, 40(10), 881-889.
  7. American Migraine Foundation. (2021). Migraine and the menstrual cycle. https://americanmigrainefoundation.org/resource-library/migraine-and-the-menstrual-cycle/
  8. O’Brien, H. L., et al. (2013). Investigating the effectiveness of interventions to increase patient adherence to preventive migraine medication: A systematic review. Cephalalgia, 33(4), 224-235.
  9. Tepper, S. J. (2018). History and review of anti-CGRP monoclonal antibodies in migraine prevention. Headache, 58(S1), 238-245.
  10. American Migraine Foundation. (2021). Botox for migraine: What to expect. https://americanmigrainefoundation.org/resource-library/botox-migraine-expect/
  11. Silberstein, S. D., et al. (2017). Erenumab for episodic migraine: Interim results of a US-based randomized, double-blind, placebo-controlled phase 3 trial. Cephalalgia, 37(9), 985-997.
  12. Mayo Clinic. (2021). Migraine with aura: Diagnosis & treatment. https://www.mayoclinic.org/diseases-conditions/migraine-with-aura/diagnosis-treatment/drc-20353369
  13. Lipton, R. B., et al. (2020). Effect of fremanezumab compared with placebo for prevention of episodic migraine: A randomized clinical trial. JAMA, 323(22), 2240-2250.
  14. Hershey, A. D., et al. (2002). American Headache Society Quality Standards Subcommittee and American Academy of Neurology. Guidelines for controlled trials of prophylactic treatment of chronic migraine in adults. Cephalalgia, 22(9), 697-710.
  15. Dodick, D. W., et al. (2018). Safety and efficacy of ALD403, an antibody to calcitonin gene-related peptide, for the prevention of frequent episodic migraine: A randomised, double-blind, placebo-controlled, exploratory phase 2 trial. The Lancet Neurology, 13(11), 1100-1107.
  16. Rothrock, J. F., et al. (2010). Cognitive-behavioral therapy for migraine in children and adolescents: A randomized pilot trial. Headache, 50(6), 953-961.
  17. The Migraine Trust. (2021). Migraine and diet. https://www.migrainetrust.org/about-migraine/migraine-what-is-it/more-than-just-a-headache/migraine-and-diet/
  18. American Migraine Foundation. (2021). Managing your diet to prevent migraines. https://americanmigrainefoundation.org/resource-library/managing-your-diet-to-prevent-migraines/
  19. American Migraine Foundation. (2021). Can dehydration trigger migraines? https://americanmigrainefoundation.org/resource-library/can-dehydration-trigger-migraines/
  20. Russo, A. F. (2015). Calcitonin gene-related peptide (CGRP): A new target for migraine. Annual Review of Pharmacology and Toxicology, 55, 533-552.

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